PGA & HA: Mmelite mmekọrịta, Kwuo Nnọọ na Nrapara, Moisturizing na Antioxidant Duet

# Okwu mmalite

Sodium polyglutamate (PGA)bụ polymer-soluble mmiri emepụtaramicrobial gbaa ụka.A na-eji ya eme ihe n'ọtụtụ ebenlekọta anụ ahụngwaahịa naihe ịchọ mman'ihi ezigbo moisturizing Njirimara na multifunctional Njirimara.Isiokwu a ga-ewebata isi iyi, chemical Ọdịdị, àgwà na ngwa nkesodium polyglutamatena ngwaahịa nlekọta anụ ahụ n'ụzọ zuru ezu.

#Isi iyi na Chemical Structure

Sodium polyglutamateAchọpụtara na mbụ na natto, nri ndị Japan omenala.Silk viscous nke ukwuu na natto bụPGA.Ihe a bụ polymerized sitere na glutamic acid eke na nke na-emebi emebi wee mepụta ya site na gbaa ụka nke Bacillus subtilis.Bacillus subtilis bụ ihe mgbakwunye microbial nchekwa (GRAS) nke mba ụwa matara, nke sitere n'okike na nchekwa maka ahụ mmadụ.

The isi Ọdịdị nkePGAIhe mejupụtara ya bụ 5000-10000 glutamic acid molecules polymerized site na.γ- amide bond.Ngwakọta ahụ nwere ọnụ ọgụgụ dị ukwuu nke polar dị ka hydroxyl na carboxyl otu, nke nwere ike ịmepụta njikọ hydrogen n'ime na n'etiti ụmụ irighiri ihe, si otú a na-ejikọta nnukwu mmiri ma na-eme ka mmetụta ya dịkwuo mma.

# Akụkụ na mmetụta

1. **Ọmarịcha moisturizing arụmọrụ**: PGA nwere ike ịmịkọrọ na igbachi nnukwu mmiri, na-eme ka hydration nke akpụkpọ ahụ dịkwuo mma.Mgbe eji yasodium hyaluronate (HA), ọ nwere ike ịgbatị oge mmiri na-ekpo ọkụ nke HA, belata nrapara ya, ma mee ka akpụkpọ ahụ dịkwuo mma ma dị mma.

2. **Ọrụ antioxidant**: PGA nwere ọrụ antioxidant, nwere ike ịzọpụta radicals efu, ma chebe akpụkpọ ahụ pụọ na mmebi oxidative.Nnyocha egosiwo na PGA nwere ihe dị arọ nke 1.4 nde Da na-arụ ọrụ dịtụ mma karịa PGA na ịdị arọ molekụla nke 1 nde Da na-ekpochapụ DPPH free radicals.

3. **Mee ka ọdịnaya nke ihe na-eme ka ọ dị mma (NMF) dị na akpụkpọ ahụ**: PGA nwere ike ịkwalite ọgbọ nke NMF na akpụkpọ ahụ, welie ike nke moisturize anụ ahụ, ma nweta mmetụta nke nri miri emi.

4. **Ịcha ọcha na mgbochi ịka nká**: PGA nwere ike iji nwayọọ na-achịkwa ọrụ nke tyrosinase, na-egbu oge ịmepụta ntụpọ, ma n'otu oge ahụ melite nkwụsi ike nke HA na akpụkpọ ahụ, mee ka ọdịnaya HA dịkwuo elu, ma nweta mmetụta nke ịcha ọcha na mgbochi ịka nká.

# Arọ Molecular na Ngwa

Dị ka ihe dị arọ nke molekụla si dị, PGA nwere ike kewaa n'ime ụdị atọ: ịdị arọ dị elu, ịdị arọ nke ọkara na obere molecular arọ, nke ọ bụla nwere àgwà na ngwa dị iche iche:

- **PGA-HMW (ịdị arọ molekụla dị elu,> 700kDa)**: mmiri na-adịte aka, na-eme ihe nkiri na-eme ka mmiri dị n'elu anụ ahụ, na-eme ka mmetụta nke moisturize dịkwuo mma.

- **PGA-LMW (obere molekụla arọ, 70-150kDa)**: moisturize na ịcha ọcha, na-eme ka nchapụta anụ ahụ dịkwuo mma na nhịahụ.

- **PGA-Oligo (dị arọ molekụla dị ala, <10kDa)**: nri miri emi, na-erute oyi akwa basal ozugbo, na-akwalite ọgbọ NMF na nnabata nke nri.

# Ngwa na jiri aro

PGA dabara maka moisturize, mgbochi ịka nká na ngwaahịa ịcha ọcha, yana ntinye akwadoro nke0.1% ruo 1%.Ekwesịrị iji ihe mgbochi ionic emulsifiers mee ihe dịka o kwere mee na usoro iji bulie mmetụta PGA.

# Mmechi

Dị ka ihe okike, nchekwa na arụ ọrụ biopolymer,sodium polyglutamate (PGA)na-egosi nnukwu ngwa ngwa na ngwaahịa nlekọta anụ ahụ na ihe ịchọ mma.Ngwongwo mmiri ya mara mma, ọrụ antioxidant na ọtụtụ uru ahụike anụ ahụ na-eme ka ọ bụrụ ihe dị mkpa na ngwaahịa nlekọta anụ ahụ nke oge a.Site na mmụba nke nyocha na ọganihu nke teknụzụ ngwa,PGAa na-atụ anya na ọ ga-arụ ọrụ dị mkpa na mpaghara ndị ọzọ ma weta ihe ọhụrụ na mmepe na teknụzụ nlekọta anụ ahụ.